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these are several questions that need to be answered.
2.The nanocarrier needs to remain in suspension in H2O, PBS (PhosphateBuffered
Saline), human serum, etc. What type
of polymer do you need to use to decorate the surface of the nanocarrier to achieve this goal?. Hint: Remember this
polymer also prevents the adsorption of proteins and evades the immune system.
3. Write the chemical structure of this polymer. Hint: If you do not remember the chemical structure
of this polymer at least mention which functional groups should be present in the chemical structure of the polymer to be
soluble in H2O.
4.Which are the most important configurations that this polymer needs to have to reduce protein adsorption?.
5. If your nanocarrier is synthesized with PLGA polymer, what monomer ratio (X:Y)( 50:50, 75:25:, 25:75) will you use to
synthesize a nanocarrier that hydrolyze fast. Explain your answer writing the chemical structure of PLGA.
6.Would you use an amorphous or crystalline PLGA polymer or a mixture or both to synthesize your nanocarrier?. Explain
your answer.
7.Which configurations does your nanocarrier need to have to highly reduce protein adsorption and evade the immune
system?. Please explain your answer.
8.What will be the size and charge of the designed nanocarrier?. Please explain your answer by explaining why you have
selected a specific size and charge in relation to the therapeutic effectiveness of the nanocarrier.
9. Draw the shape of the designed nanocarrier and explain the elements that form it.
10.Write the chemical entity of each constituent. For example, X is a hydrophobic molecule while Y is hydrophilic molecule.
11. If the nanocarriers was not designed “well” in which organs of the human body or animal body will the nanocarrier end
up?. Please explain your answer.
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12.If the complement system is activated by the presence of the nanocarrier, do you think the carrier will reach the target
tissue?. If yes, explain why?. If not, explain why?.
13. If the drug delivery system is administered subcutaneous do you think that the complement system will be activated.
Please explain your question.
14.What type of drug would you encapsulate in the nanocarrier, hydrophobic or hydrophilic?.
15.If you find out that the hydrolysis rate of the chosen polymer is very slow. How would you accelerate the process of
releasing the drug in the target?. Would you use triggeredrelease
system mechanisms such as pH, temperature, magnetic
