What is the mechanism of action of the glycoprotein IIb/IIIa antagonists and their clinical indications?
Type of document Essay 1 Page Subject area Nursing Academic Level Master
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Tanya Champion
WEEK 8 DT 1
COLLAPSE
What is the mechanism of action of the glycoprotein IIb/IIIa antagonists and their clinical indications?
Glycoprotein IIb/IIIa antagonists can prevent platelet aggregation, thrombus formation, and distal thromboembolism while protecting initial platelet binding to damaged vascular surfaces. Platelet activation happens when an event results in the binding of any number of agonists. Agonist binding results in cell receptor activation. After binding to damaged tissue, platelets are activated and undergo a change. The glycoprotein IIb/IIIa inhibitors then interfere with platelet activity at the final common pathway of platelet-induced thrombosis. All the GP IIb/IIIa antagonists function by preventing platelet aggregation, which contributes to acute thrombus formation and distal platelet thromboembolism. (Shlansky-Goldberg, 2002) Their clinical indications are for patients with coronary artery disease.
Reference:
Shlansky-Goldberg, R. (2002). Platelet aggregation inhibitors for use in peripheral vascular interventions: what can we learn from the experience in the coronary arteries? J Vasc Interv Radiol: 13(3):229–246.
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