topic;pharmacology
1- In this assignment activities, you need to answer all questions below in Workbook Learning Activities for Module 3. please try to cover the whole points and also . Also you are free to use your own reading resources you are not limited by my provided reading recourses Also: 1- Wikipedia, DrugBank and Medipedia are NOT acceptable as drug information source. Use of these sites does not allow you to demonstrate conceptual understanding of the topic material and will not meet the learning objectives of this topic. These sites are not peer-reviewed and frequently contain inaccurate information that could lead to inappropriate practices. Similarly, MIMS and eMIMS are not acceptable as pharmacology reference sourcesas the information they contain is nothing more than the approved product information. 2-all assignments we will be passing through (Turnitin) text matching software, this software is part of the University Academic Integrity policy. please note that all references have to be after 2009 and they should be peer reviewed journals. It prefers to get new jounals – date 2012 & 2011- peer reviewed articles.
2- Please when you answer the questions – write every single question followed by the answer, exactly, as same as the orders below.
3- Please be specific with (in text reference) & (reference list). As Harvard.
4- Be aware that there are a lot of my friends dealing with your company. They have same assignment. So, please as I trust that your are professional writer, I expected that you will provide me by a original papers. I’m sorry for saying that but just to avoid plagiarism & this happened many times then they got fail the topic. So, please I trust you.
Workbook Learning Activities for Module 3
Section 2. Drug Metabolism
1. Referring to the primary literature, investigate the metabolism of paracetamol
1. Draw a diagram to show the metabolic pathways of paracetamol. On the diagram indicate the enzyme (CYP, UGT, SULT) responsible for each pathways. (write the answer here).
2. Explain how the metabolism of paracetamol contributes to the hepatotoxicity caused by this drug. (write the answer here).
3. Explain the mechanism of action of N-acetylcysteine as an antidote for the treatment of paracetamol overdose. (Total 10 marks) (write the answer here).
Section 4. Drug-Drug Interactions
1. A direct pharmacodynamic interaction is the cornerstone of the treatment of opioid (mainly heroin) overdose.
• Explain briefly the mechanism of action of opioid agonists, such as morphine.
• List the physiological effects observed with opioid overdose.
• Explain the pharmacological basis for the treatment of opioid overdose with naloxone, including the time-course of naloxone treatment. (Total 6 marks)
2. Answer the following:
• Explain briefly the mechanism of the pharmacokinetic interaction between amiodarone and warfarin. Comment on the potential clinical implications of this interaction.
• Explain briefly the mechanism of the pharmacokinetic interaction between St John’s wort and midazolam. Comment on the potential clinical implications of this interaction. (Total 4 marks)
