the structure , function and physiological role of inwardly rectifying kir 2.1, 2.2 ,2.3 and 2.4 channels in the heart and brain
One paragraph summary of everything
*Introduction
⢠Different types of k channels ( in general )
⢠Sites where they are found
⢠Focus on â Kir 2.1 kir 2.2 kir 2.3 and kir 2.4â in Heart and brain
⢠Brief summary of
1_Structure: Two transmembrane
domain
2_Function: Regulate ion movement ,Cell membrane electricity
*body:
Structure
Description of
1Molecular
& Stoichiometry
2t
wo transmembrane
domain
3Gating
mechanisms
4Diagram
( if there is a missing structure of the kir 2.x channels that i did not put it , mention it please )
Function
_ in the Brain
_ in the Heart
_How are they regulated??
_Mechanism of action
_PIP2 and channel activation
Physiological role
⢠Brain
o Regulating resting membrane potential of the cell.
o Their function modulated by neurotransmitters
⢠Heart
o In the nodal cells
o Slowing repolarization
o Prolonging action potential
o Resting membrane potential
_ and other functions that they do in the heart and brain
Diseases
⢠Neurological :Andersen’s syndrome / Kir2.1/ KCNJ2
⢠Cardiac :Short QT syndrome/ Kir2.1/ KCNJ2
